DNAFET
DNA field-effect transistor is a field effect transistor (or FET) using field effect generated by the partial charges of the DNA molecules to act as a biosensor. The structure of DNAFET is similar to that of the MOSFET, with the exception of the gate structure, in the DNAFET, is replaced by a layer of molecules of single strands of DNA that act as surface receptors. When complementary DNA strands hybridized receptors change the load distribution near the surface, which modulates the current transport through the semiconductor transducer.
chips can be used DNAFET to detect single nucleotide polymorphisms (which can cause various inherited diseases) and DNA sequencing. Its main advantage compared to optical detection methods commonly used today, is that they require the labeling of molecules. In addition, work continuously and (almost) in real time. The DNAFET are highly selective and specific binding only modulate the transport of cargo.
is a biosensor, an instrument for measuring biological and chemical parameters. Usually combine a component of a biological and a physical-chemical.
It consists of three parts:
- The biological sensor, can be a tissue, a culture of microorganisms, enzymes, antibodies, acid chains nucleic acids, etc. The sensor can be borrowed from nature or be a product of synthetic biology.
- The transducer: It connects the other two elements and translates the signal from the sensor.
- The detector: It can be optical, piezoelectric, thermal, magnetic, etc.
CI. 16745566.
Subject: CAF.
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